RAK
    Fosforylacja Tau T205 moduluje rekrutację komórek engramu i pamięć odległą u myszy - Nature Communications

    Fosforylacja Tau T205 moduluje rekrutację komórek engramu i pamięć odległą u myszy - Nature Communications

    519 odsłon
    0
    RAK Exa Editorial Beats

    The study investigates the role of tau protein phosphorylation in memory formation in mice. It finds that tau phosphorylation at threonine-205 (T205) is crucial for remote memory formation by regulating engram cell recruitment and preventing extraneous cell activation, linking sensory cues to the encoding ensemble. Pathogenic tau induces aberrant activation and amnesia.

    Acknowledgements

    The authors thank Yee Lian Chew and Fabien Delerue for discussions on experimental design, Holly I Ahel, Alexander M Volkerling and Dan Thorpe for technical assistance, Microscopy Australia, Biomedical Engineering and Preclinical Services for assistance. Subsidised access to the UNSW Bioanalytical Mass Spectrometry Facility is gratefully acknowledged.

    Funding

    This work was supported by funding from the National Health and Medical Research Council (grant nos. 1143978, 1176628, 2028265) to A.I. and (grant nos. 2029740, 2020624) to L.I.; from the Australian Research Council (grant nos. DP200102396 and DP220101900) to A.I. and (grant no. DP240101654) to L.I.; from the Flinders Foundation, and Flinders University to A.I.; from the BrightFocus Foundation (grant no. A2022022F) to K.S.; from Dementia Australia Research Foundation to A.I., K.S., E.P. K.S. was supported by a Scientia Professor Henry Brodaty Post-doctoral Fellow of the Dementia Australia Research Foundation. A.I. was supported by a National Health and Medical Research Council Emerging Leadership grant. Microscopy Australia is supported by NCRIS and the government of South Australia at Flinders Microscopy and Microanalysis (ROR: 04z91ja70), Flinders University (ROR: 01kpzv902).

    Author information

    Author notes

    1. Emmanuel Prikas

      Present address: NYU Centre for Neural Science, New York University, New York, NY, USA

    2. Josefine Bertz

      Present address: Nuvisan The Science CRO, Berlin, Germany

    3. These authors contributed equally: Renée Kosonen, Kristie Stefanoska.

    Authors and Affiliations

    1. Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia

      Renée Kosonen, Kristie Stefanoska, Yijun Lin, Samantha Edwards, Emmanuel Prikas & Arne Ittner

    2. Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia

      Josefine Bertz & Lars M. Ittner

    3. Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia

      Anne Poljak

    Authors

    1. Renée Kosonen
    2. Kristie Stefanoska
    3. Yijun Lin
    4. Samantha Edwards
    5. Emmanuel Prikas
    6. Josefine Bertz
    7. Anne Poljak
    8. Lars M. Ittner
    9. Arne Ittner

    Corresponding author

    Correspondence to Arne Ittner.

    Ethics declarations

    Competing interests

    A.I. and L.M.I. are inventors on patents related to targeting p38γ and Thr-205 tau in Alzheimer’s and other neurological conditions (US Patent App. 17/931,229; US Patent App. 17/754,047; AU Patent 2,020,353,719) licensed to Celosia Therapeutics. L.M.I. is a shareholder of Celosia Therapeutics. The remaining authors declare no competing interests.

    Additional information

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    Rights and permissions

    Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Kosonen, R., Stefanoska, K., Lin, Y. et al. Tau T205 phosphorylation modulates engram cell recruitment and remote memory in mice. Nat Commun (2026). https://doi.org/10.1038/s41467-026-73207-9

    • Received: 06 May 2025

    • Accepted: 06 May 2026

    • Published: 17 May 2026

    • DOI: https://doi.org/10.1038/s41467-026-73207-9

    Źródło: RAK Exa Editorial Beats

    Artykuł sponsorowanyAD
    LOTPolskie Linie Lotnicze

    Stanowski

    Co dzisiaj majstrujemy do sekcji Świat?

    Stanowski